"They don't yet know that the good don't always win, so there's nothing you can say to cheer them up when they lose. I want to tell them disappointment doesn't last, but from what i've seen disappointment lasts like hell." - Mitch Mahoney (Putnam County Spelling Bee)
If I read this today, it would have had much more sense to me since i finally figured out what it means.
"Bad things do happen. Happiness in the face of all... that's not the goal. Feeling horrible and knowing that you're not gonna die from those feelings. That's the point." - Grey's Anatomy
So I guess this answers Mitch Mahoney's monologue.